21 May 2015 During the process of enterohepatic circulation of bile salts, it is Even though ASBT is a bile acid cotransporter closely related to NTCP, 

Sodium/bile acid cotransporter also known as the Na + - taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.

The SLC10A transporter gene family consists of seven members and substrates transported by three members (SLC10A1, SLC10A2 and SLC10A6) are Na +-dependent. SLC10A1 (sodium taurocholate cotransporting polypeptide [NTCP]) and SLC10A2 (apical sodium-dependent bile salt transporter [ASBT]) transport bile salts and play an important role in maintaining enterohepatic circulation of bile salts. Na+-dependent bile salt transport system in the hepatocytes of the adult lamprey, with a very low affinity for TCA (K m = 115 ± 8.7 µM). This is strikingly different from previous observations in isolated hepatocytes from skate and rainbow trout1,2 that appear to lack a Na+-dependent TCA transporter. 2000-04-01 · In addition to sodium/bile salt cotransport, sodium-independent bile salt transport pathways are also present at the basolateral plasma membranes of hepatocytes (8, 9, 11). These sodium-independent bile salt uptake systems have been less well characterized compared with the sodium-coupled uptake carrier, a fact that is reflected by the broad range of reported apparent K m values between 9 and However, both stomatin overexpression and knockdown increased NTCP-mediated taurocholate uptake while NTCP abundance at the plasma membrane was only increased in stomatin depleted cells. These findings identify stomatin as an interactor of NTCP and show that the interaction modulates bile salt transport.

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It is also capable of transporting other solutes and is necessary for the entry of hepatitis B and hepatitis D viruses into the hepatocyte. The Na-K-Cl cotransporter is a protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. In humans there are two isoforms of this membrane transport protein, NKCC1 and NKCC2, encoded by two different genes. Two isoforms of the NKCC1/Slc12a2 gene result from keeping or skipping exon 21 in the final gene product.

In man, two well-characterized members and three orphan transporters are known. The importance of membrane voltage in uptake of bile salts into hepatocytes is not known.

1992-08-01

2. Gångarna i salivkörtlarna påverkas av hormon där Na+/K+ reabsorbtion sker via Aldosteron. Alltså kommer HCO3- ger alltså skydd mot saltsyran. Kolhydrater Efter detta kan de transporteras in i cellen via Co-transport med H+.Cellens  Julvi Hus i Göteborg AB. 031497575.

Cotransport · The direct hydrolysis of ATP (primary active transport) · By coupling with the transport of another molecule moving along its electrochemical gradient (  

It has an important physiological function as the first step in bile acid (BA) reabsorption from the intestine, playing a key role in the enterohepatic recirculation of BAs [1]. Although ASBT is expressed in other organs, its functions there are largely unexplored. Bile salt transport proteins in rat and human liver At the basolateral membrane, the chief uptake systems for conjugated bile salts are the Na -taurocholate cotransporting polypep- involved in bile salt transport. Methods: LPS and cyto-pletely defined, it is well recognized that hepatocellular bile kines were administered to Sprague–Dawley rats or salt uptake occurs via sodium-dependent cotransport, 5,6 and C57BL/6 mice, and the expression and function of he-patocyte transporters involved in bile salt secretion the 1994-05-01 · The Na(+)-independent transport system exhibits a substrate specificity, which is different from the specificity of Na(+)-dependent bile salt transport in mammals. Unconjugated and conjugated di- and tri-hydroxylated bile salts inhibit uptake of cholyltaurine and cholate competitively. Hepatocellular bile salt uptake is mediated predominantly by the Na + -taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na + -independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans). After diffusion (bound by intracellular bile salt–binding proteins) to the canalicular patic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na -dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na - taurocholate cotransporting polypeptide NTCP (SLC10A1).

Methods: mRNA levels (real time PCR) and protein expression (immunofluorescence microscopy) were investigated for the Na(+)-taurocholate cotransport protein (Ntcp), the organic anion transporting polypeptides (Oatp1a1, Oatp1a4, Oatp1b2), the multidrug resistance associated proteins (Mrp2, Mrp6) and the bile salt export pump (Bsep).
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Bile salt uptake into the hepatocyte is predominantly mediated by the Na +-taurocholate-cotransporting polypeptide (NTCP), and, to a lesser extent, by the organic anion transporting protein (OATP) family.

NTCP/SLC10A1 (humans) and Ntcp/ Slc10a1 (rodents) are localized on the basolateral/sinusoidal domain of hepatocytes and their main function is the extraction of bile acids from portal blood, ultimately leading to their biliary 2003-04-01 Sigma-Aldrich offers abstracts and full-text articles by [Michael Trauner, James L Boyer].
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Na+-dependent bile salt transport system in the hepatocytes of the adult lamprey, with a very low affinity for TCA (K m = 115 ± 8.7 µM). This is strikingly different from previous observations in isolated hepatocytes from skate and rainbow trout1,2 that appear to lack a Na+-dependent TCA transporter.

Electrogenicity of the primary bile salt transport process, Na-bile salt cotransport, has been difficult to determine because  ASBT (apical sodium-dependent bile acid transporter). Aliases: IBAT Hagenbuch, B. and P. Dawson, The sodium bile salt cotransport family SLC10. Pflugers  porting polypeptide (NTCP), the bile salt export pump. (BSEP), the apical sinusoidal membrane by the Na + taurocholate cotransport- ing polypeptide with   They are related to the human bile acid:sodium symporters (TC 2.A.28) functioning in the liver in the uptake of bile acids from portal blood plasma, a process mediated by the co-transport of Na+ Indriolo E, Na G, Ellis D, Salt DE, Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on K14341, solute carrier family 10 ( sodium/bile acid cotransporter), member 1 K11822, bile-salt sulfotransferase [ EC:2.8. Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in  21 May 2015 During the process of enterohepatic circulation of bile salts, it is Even though ASBT is a bile acid cotransporter closely related to NTCP,  20 Oct 2020 Hagenbuch, B, Dawson, P. The sodium bile salt cotransport family SLC10. Kinetic characterization of bile salt transport by human NTCP  As a cotransporter, NTCP binds two sodium ions and one (conjugated) bile salt molecule, thereby providing a hepatic influx of bile salts. Other transported  3.