Hyperalgesia distant to the wound, or secondary hyperalgesia, occurred in response to punctate mechanical stimuli, was short-lived, and required greater forces. These results suggest that the most persistent pain behaviors in this model are largely primary hyperalgesia.

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1. Psychophysical studies were made, in humans, of the sensory characteristics and underlying mechanisms of the hyperalgesia (often termed “secondary hyperalgesia”) that occurs in uninjured skin surrounding a local cutaneous injury.

In a new study reported in Pain, scientists from However, the secondary hyperalgesia to punctate mechanical stimuli, that occurs as a result of central neuronal plasticity of the nociceptive system is mediated by A-fiber nociceptors, not C-fibers [11–14]. Thus, secondary hyperalgesia as a result of central sensitization elicited by BTS may be significantly distinct from HPDT. Areas of secondary hyperalgesia and LTS painfulness returned to baseline levels by the time of the third rekindling, demonstrating rapid disappearance of remifentanil analgesia and possibly transient spontaneous opioid withdrawal hyperalgesia. Primary hyperalgesia occurs at and around the site of the injury. Secondary hyperalgesia occurs when the pain feels as if it’s spreading to a non-injured site of the body.

Secondary hyperalgesia

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Summary diagram illustrating a significant supraspinal contribution to secondary, but not primary, thermal hyperalgesia after peripheral inflammation. 4 Feb 2015 Secondary hyperalgesia involves the surrounding uninjured area. (Copyright Cleveland Clinic Foundation.) Each sensory cell has specific  Secondary Hyperalgesia Phenotypes Exhibit Different Brain Activation Patterns During Noxious Stimulation. Forskningsoutput: Konferensbidrag ›  Secondary hyperalgesia is inducible in most individuals and is attributed to central neuronal sensitization. Some individuals develop large areas of secondary  Hyperalgesia.

Static allodynia is generally short lasting and confined to the primary hyperalgesic area (primary hyperalgesia), whereas dynamic and punctate hyperalgesia extends beyond this area (secondary hyperalgesia). Allodynia is a condition in which pain is caused by a stimulus that does not normally elicit pain. For example, bad sunburn can cause temporary allodynia, and touching sunburned skin, or running cold or warm water over it, can be very painful.

23 Jan 2015 Noxious stimulation of the skin with either chemical, electrical or heat stimuli leads to the development of primary hyperalgesia at the site of 

It is Allodynia is a condition in which pain is caused by a stimulus that does not normally elicit pain. For example, bad sunburn can cause temporary allodynia, and touching sunburned skin, or running cold or warm water over it, can be very painful. 2019-07-18 · Hyperalgesia Increased response to a normally painful stimulus.

Secondary hyperalgesia

23 Jan 2015 Noxious stimulation of the skin with either chemical, electrical or heat stimuli leads to the development of primary hyperalgesia at the site of 

Hyperalgesia distant to the wound, or secondary hyperalgesia, occurred in  19 Aug 2019 Secondary hyperalgesia—increased pain to a stimulus that is normally painful, in the area outside that of tissue damage or stimulation—is a  23 Jan 2015 Noxious stimulation of the skin with either chemical, electrical or heat stimuli leads to the development of primary hyperalgesia at the site of  136, 378).

Exp Neurol 1998;149:193–202. 25. osteoarthritis: secondary analysis of a randomised controlled trial. Assessing movement and function How hyperalgesia and allodynia  The reality that established hyperalgesia and allodynia can be reversed close Lung abscess secondary to parenchymal disease, carcinoma, machiavellian  85–106. 24. Pertovaara A. A neuronal correlate of secondary hyperalgesia in the rat spinal dorsal horn is submodality selective and facilitated  NCT03065842, Social Stigma more >> Pregnancy Contraception Collapse <<, Not Applicable, Completed, -, Kenya more >> Secondary schools in Kisumu  Svärd L. Lowering of the Patella Secondary to Anterior Advancement Generalised Muscular Hyperalgesia in Chronic Whiplash Syndrome.
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Secondary hyperalgesia to pinprick and stroke around burn injury, right calf 130–150 min Side effects Area of secondary hyperalgesia to pinprick during brief conditioning, thigh HPDT, right (burned) and left calf Area of secondary hyperalgesia to pinprick and stroke around burn injury, right calf 150 min Cessation of i.v. infusion with Assessment of secondary hyperalgesia: The area of secondary hyperalgesia was quantified after stimulation with a monofilament (Von Frey hair) with a nominal value of 18 (bending force 490 mN) in 4 linear paths arranged in 90˚ around the center of the thermode.

A brief cognitive-behavioural intervention for pain reduces secondary hyperalgesia Tim V. Salomonsa,b,c, Massieh Moayedia,d,e, Nathalie Erpeldinga, Karen D. Davisa,d,f,⇑ a Division of Brain, Imaging and Behaviour—Systems Neuroscience, Toronto Western Research Institute, Toronto, Ontario, Canada Experiment 1: Primary and Secondary Hyperalgesia Testing After Plantar Incision.
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How precise does the Max. VAS-score following Long Thermal Stimulation evaluated on the 4 experimental days predict the size of the area of secondary hyperalgesia on the respective 4 experimental days? 4 sessions of Long Thermal Stimulation on 4 separate experimental days with 1 session per experimental day.

Another kind of hyperalgesia is The focal form is typically associated with injury, and is divided into two subtypes: Primary hyperalgesia describes pain sensitivity that occurs directly in the damaged tissues. Secondary hyperalgesia describes pain sensitivity that occurs in surrounding undamaged tissues.


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Allodynia is a condition in which pain is caused by a stimulus that does not normally elicit pain. For example, bad sunburn can cause temporary allodynia, and touching sunburned skin, or running cold or warm water over it, can be very painful.

Hyperalgesi. Svensk definition.